hATTR Compass™ Genetic Testing Program Continues to Expand and Enable Diagnosis and Treatment of Hereditary ATTR Amyloidosis One Year Following Launch
BOSTON and Aliso Viejo, Calif.,
To date, over 700 physicians across the United States, Canada and Puerto Rico have utilized hATTR Compass to help hundreds of people learn if they carry any of the TTR gene mutations associated with hATTR amyloidosis. hATTR Compass screens for up to 81 genes that cause hereditary polyneuropathies and up to 92 genes associated with hereditary cardiomyopathies, including hATTR amyloidosis. The hATTR Compass program helps accelerate or confirm the diagnosis of hATTR amyloidosis while providing support and resources to people and healthcare professionals throughout the genetic testing process.
hATTR amyloidosis is an autosomal dominant genetic disease, which means every first-degree relative of an affected patient has a 50 percent chance of having the same gene mutation. Because of this, those living with hATTR amyloidosis often suffer the dual burden of watching older loved ones suffer with the disease, while also fearing what the future could hold for their children or grandchildren.
“We now know that if you have hATTR, the sooner you can start treatment, the better, underscoring the importance of early diagnosis through genetic testing. With hATTR Compass and the help of our family’s physician, we were able to test 27 family members for the genetic variants that cause hATTR amyloidosis in one day,” said Angel Male, an hATTR Compass participant and family caregiver. “Each person’s individual results – positive or negative – have helped us proactively take control of our futures. We know who is at risk, what symptoms to look for and are empowered to begin seeking treatment that will slow the disease down and allow us to maintain our independence for as long as possible.”
As hATTR amyloidosis progresses, patients may experience symptoms that initially present as tingling, numbness or pain of neuropathy. These symptoms can progress to include carpal tunnel syndrome caused by amyloid depositions, chronic nausea and gastrointestinal distress. Due to the historic absence of treatment options, and the disparate nature of these symptoms, hATTR amyloidosis is often not suspected or diagnosed, leading to multiple specialist visits, years of searching for answers and, often times, inappropriate treatment for a misdiagnosed condition.
“hATTR amyloidosis is a zebra with many different stripes,” said Andrew Darlington, DO,
Akcea and Ambry recently expanded their hATTR Compass partnership which includes increasing their salesforce and marketing efforts to drive additional awareness and education for patients and physicians.
“hATTR Compass has helped enable early diagnosis and treatment for people who are suffering from this rapidly progressive disease and it allows them to get answers about their disease from their own local physician,” said Sarah Boyce, President at Akcea Therapeutics. “ As a result of hATTR Compass, as well as a new treatment that can be administered by the patient or caregiver, Akcea is helping patients receive the answers they seek, obtain the life-changing treatment they need and maintain the independence they cherish in the comfort of their own communities.”
“hATTR amyloidosis is a complex disease that requires the kind of sophisticated tool offered by Ambry Genetics for proper diagnosis. We are pleased to expand our partnership with Akcea to further our commitment to supporting physicians, patients and their families through offering access to our high-quality and comprehensive genetic testing that can identify at-risk patients,” said Tom Schoenherr, Chief Commercial Officer of Ambry Genetics.
ABOUT hATTR COMPASS™
hATTR Compass is a no-cost, confidential genetic testing and genetic counseling program for people with suspected hereditary (hATTR) amyloidosis. hATTR Compass screens for up to 81 genes that cause hereditary polyneuropathies and up to 92 genes associated with hereditary cardiomyopathies, including hATTR amyloidosis. The hATTR Compass program helps accelerate or confirm the diagnosis of hATTR amyloidosis while providing support and resources to people and healthcare professionals throughout the genetic testing process.
To be eligible for hATTR Compass, people must be in the U.S., Canada and Puerto Rico, 18 years or older, and are either experiencing red flag symptoms of hATTR amyloidosis or are aware of a family history of hATTR amyloidosis, including polyneuropathies and cardiomyopathies.
Confidential genetic counseling is part of the hATTR Compass program, which enables confidential access to diagnostic testing, treatment and professional guidance. Genetic testing results will only be provided to people and their healthcare providers to ensure the protection of confidential patient information.
Akcea has also partnered with
To learn more about hATTR Compass and the testing process, please visit www.hattrcompass.com.
ABOUT HEREDITARY TRANSTHYRETIN (hATTR) AMYLOIDOSIS
Hereditary ATTR amyloidosis is a severe, progressive, and life-threatening disease caused by the abnormal formation of the TTR protein and aggregation of TTR amyloid deposits in various tissues and organs throughout the body, including in peripheral nerves, the heart and intestinal tract. The progressive accumulation of TTR amyloid deposits in these organs often leads to intractable peripheral sensorimotor neuropathy, autonomic neuropathy, and/or cardiomyopathy, as well as other disease manifestations. Hereditary ATTR amyloidosis causes significant morbidity and progressive decline in quality of life, severely impacting activities of daily living. The disease often progresses rapidly and can lead to premature death. The median survival is 4.7 years following diagnosis. Additional information on hereditary ATTR amyloidosis, including a full list of organizations supporting the hATTR amyloidosis community worldwide, is available at www.hattrchangethecourse.com or by visiting www.hATTRGuide.com.
ABOUT AKCEA THERAPEUTICS
ABOUT AMBRY GENETICS CORPORATION
Ambry Genetics, as part of Konica Minolta Precision Medicine, excels at translating scientific research into clinically actionable test results based upon a deep understanding of the human genome and the biology behind genetic disease. Our unparalleled track record of discoveries over 20 years, and growing database that continues to expand in collaboration with academic, corporate and pharmaceutical partners, means we are first to market with innovative products and comprehensive analysis that enable clinicians to confidently inform patient health decisions. We care about what happens to real people, their families, and the people they love, and remain dedicated to providing them and their clinicians with deeper knowledge and fresh insights, so together they can make informed, potentially life-altering healthcare decisions. For more information, please visit www.ambrygen.com.
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Source: Ambry Genetics Corporation